Α. Εργασίες & μελέτες που αφορούν το Biobran:

[2023] Mamdooh Ghoneum, Shaymaa Abdulmalek and Hewida H. Fadel
Biobran/MGN-3, an Arabinoxylan Rice Bran, Protects against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An In Vitro and In Silico Study
Nutrients 2023, 15(2), 453; https://doi.org/10.3390/nu15020453

[2021] Ahmed F. Elsaid,* Sudhanshu Agrawal, Anshu Agrawal, and Mamdooh Ghoneum
Dietary Supplementation with Biobran/MGN-3 Increases Innate Resistance and Reduces the Incidence of Influenza-like Illnesses in Elderly Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Clinical Trial
Nutrients. 2021 Nov; 13(11): 4133.. doi: 10.3390/nu13114133 PMCID: PMC8618540 PMID: 34836388

[2021] Μ. H. Ghoneum, N. S. El Sayed,
“Protective Effect of Biobran/MGN-3 against Sporadic Alzheimer’s Disease Mouse Model: Possible Role of Oxidative Stress and Apoptotic Pathways“,
Oxidative Medicine and Cellular Longevity, vol. 2021, Article ID 8845064, 15 pages, 2021. https://doi.org/10.1155/2021/8845064

[2020] Dorothy Faye S. Tan, MD; Jerickson Abbie S. Flores, MD Jose R. Reyes
Memorial Medical Center 2nd place, Philippine College of Radiology Research Contest, Oral Presentation.
“The Immunomodulating Effects of Arabinoxylan Rice Bran (Lentin) on Hematologic Profile, Nutritional Status and Quality of Life among Head and Neck Carcinoma Patients Undergoing Radiation Therapy: A Double Blind Randomized Control Trial”.
Radiology Journal Volume 12, February 2020.

[2020] Nariman K. Badr El-Din, Doaa A. Alia, Reem Othmana, Samuel W. Frenchb, Mamdooh Ghoneum
Chemopreventive role of arabinoxylan rice bran, MGN-3/Biobran, on liver carcinogenesis in rats
Biomedicine & Pharmacotherapy Volume 126, June 2020, 110064 https://doi.org/10.1016/j.biopha.2020.110064

[2019] Z Zhaoa, W Chengb, W Quc, K Wangd,*
“Arabinoxylan rice bran (MGN-3/Biobran) alleviates radiation-induced intestinal barrier dysfunction of mice in a mitochondrion-dependent manner”.
Dep. of General Surgery, The Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, Jiangsu  China Dep. of General Surgery, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing China, Dep. of Pharmacy, The Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, China Dep. of Gastrointestinal Surgery, The Affiliated Hospital of Xuzhou Medical University, Jiangsu  China.
Biomedicine & Pharmacotherapy 124 (2020) 109855 journal homepage: www.elsevier.com/locate/biopha

[2019 ] N K. Badr El-Din,*, S K. Areida, K O. Ahmed and M Ghoneum.
“Arabinoxylan rice bran (MGN-3/Biobran) enhances radiotherapy in animals bearing Ehrlich ascites carcinoma”.
Journal of Radiation Research, 2019, pp. 1–12 doi: 10.1093/jrr/rrz055Regular Paper. Data were presented at the American Association for Cancer Research (AACR) Annual Meeting in Atlanta, Georgia. March 29–April 3, 2019.

[2019 ] F. Elsaid1 ·R. M. Fahmi2 ·M. Shaheen3 M. Ghoneum4.
“The enhancing effects of Biobran/MGN‑3, an arabinoxylan rice bran, on healthy old adults’ health‑related quality of life: a randomized, double‑blind, placebo‑controlled clinical trial”.
Quality of Life Research. https://doi.org/10.1007/s11136-019-02286-7. Accepted: 24 August 2019© Springer Nature Switzerland AG 2019

[2018 ] J E. Lewis, S E. Atlas, M H. Abbas, A Rasul, A Farooqi, L A. Lantigua, F Michaud, S Goldberg, L C. Lages, O L. Higuera, A Fiallo, E Tiozzo, J M. Woolger, S Ciraula, A Mendez, A Rodriguez & J Konefal (edited by C Gutch PhD.)
“The Novel Effects of a Hydrolyzed Polysaccharide Dietary Supplement on Immune, Hepatic, and Renal Function in Adults with HIV in a Randomized, Double-Blind Placebo-Control Trial”
JOURNAL OF DIETARY SUPPLEMENTS https://doi.org/10.1080/19390211.2018.1494661

[2018 ] J E. Lewis , S E. Atlas, O L. Higuera, A Fiallo, A Rasul, A Farooqi, O Kromo, L A. Lantigua, E Tiozzo , J M. Woolger, S Goldberg, A Mendez, A E. Rodriguez, and J Konefal
“The Effect of a Hydrolyzed Polysaccharide Dietary Supplement on Biomarkers in Adults with Nonalcoholic Fatty Liver Disease” 
Received 5 February 2018; Accepted 12 April 2018; Published 3 May 2018

[2017 ] A F. Elsaid, M Shaheen and M Ghoneum – Dep. of Community Medicine and Public Health, Faculty of Medicine, Zagazig University, Zagazig, Al Sharqia, Egypt; Dep. of 2Internal Medicine and 3Surgery, Charles R. 
“Biobran/MGN-3, an arabinoxylan rice bran, enhances NK cell activity in geriatric subjects: A randomized, double‑blind, placebo-controlled clinical trial”
Drew University of Medicine and Science, Los Angeles, CA 90059, USA Received June 11, 2016; Accepted November 28, 2017 -DOI: 10.3892/etm.2018.5713 – EXPERIMENTAL AND THERAPEUTIC MEDICINE 15: 2313-2320. [NCBI]

[2017 ] Tibor Haito
“Urgent Necessity for Standardized and Evidence Based Plant Immunomodulators (Such As Rice Bran Arabinoxylan Concentrate/MGN-3) for the Tumor Research”
Internationa Journal of Complementary & Alternative Medicine Volume 9 Issue 3 – [2017] Institute of Pharmaceutical Chemistry, Medical University Pecs, Hungary

[2017 ] Soo Liang Ooi, MMath, BHSc (Comp Med)1, Debbie McMullen, BHSc (Comp Med)2, Terry Golombick, PhD, Dipl Nut3, and Sok Cheon Pak, PhD2
“Evidence -Based Review of BioBran/ MGN-3 Arabinoxylan Compound as a Complementary Therapy for Conventional Cancer Treatment.”
Integrative Cancer Therapies 1-14, [2017] DOI: 10.1177/ 1534735417735379.- SAGE – journals. sagepub.com/home/ict

[2016 ] Hosny Salama, Eman Medhat, Magda Shaheen, Abdel-Rahman N Zekri, Tarneem Darwish and Mamdooh Ghoneum
“Arabinoxylan rice bran (Biobran) suppresses the viremia level in patients with chronic HCV infection: A randomized trial*”
International Journal of Immunopathology and Pharmacology 1–7 2016 DOI: 10.1177/0394632016674954 iji.sagepub.com

[2015 ] Annachiara Mitrugno, Niamh Moran and Pat Metharom
“Platelets – Allies of Tumour Cells”
InTech. Additional information is available at the end of the chapter http://dx.doi.org/ 10.5772/60681 , Chapter 6 from the book The Non-Thrombotic Role of Platelets in Health and Disease [2015]
Downloaded from: http://www.intechopen.com/ books/the-non-thrombotic-role-ofplatelets-in-health-and-disease.

[2014 ] Pérez-Martínez A1, Valentín J2, Fernández L3, Hernández-Jiménez E2, López-Collazo E2, Zerbes P4, Schwörer E4, Nuñéz F5, Martín IG5, Sallis H6, Díaz MÁ7, Handgretinger R4, Pfeiffer MM4.
“Arabinoxylan rice bran (MGN-3/Biobran) enhances natural killer cell-mediated cytotoxicity against neuroblastoma in vitro and in vivo”.
1Department of Pediatric Hemato-Oncology, Hospital Universitario La Paz, Madrid, Spain, 2Innate Immune Research Group, Instituto de Investigación Hospital Universitario La Paz, Madrid, Spain, 3Clinical Research Program, Cancer Research National Centre, Madrid, Spain, 4University Children’s Hospital, University of Tuebingen, Tuebingen, Germany, 5Servicio Experimentación Animal. Instituto de Investigaciones Biom
edicas “Alberto Sols”, Consejo Superior de Investigaciones Científicas Madrid, Spain, 6School of Medicine, Cardiff University, Heath Park, Cardiff, Wales, and 7Department of Hemato-Oncology and Stem Cell Transplantation, Hospital Infantil Universitario Niño Jesús, Madrid, Spain
Cytotherapy. 2014 Dec 22. pii: S1465-3249(14)00849-4. doi: 10.1016/j.jcyt.2014.11.001.

[2014 ] GHONEUM and S. AGRAWAL Charles Drew University of Medicine and Science, Los Angeles, CA, U.S.A.; 2Division of Basic and Clinical Immunology, University of California, Irvine, CA, U.S.A.
“MGN-3/BIOBRAN ENHANCES GENERATION OF CYTOTOXIC CD8+ T CELLS VIA UPREGULATION OF DEC-20S EXPRESSION ON DENDRITIC CELLS”-
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY Vol. 27, no. 4, 523-530 (2014) Received May 17, 2014 <Accepted August 29,2014

[2014 ] M. Ghoneum, N. K. Badr El-Din, D. A. Ali and Mai Alaa El-Dein
“Modified Arabinoxylan from Rice Bran, MGN-3/Biobran, Sensitizes Metastatic Breast Cancer Cells In Vitro“
Anticancer Research January 2014, 34 (1) 81-87;

[2013] Mamdooh Ghoneum,* Nariman K. Badr El-Din, Salma M. Abdel Fattah, and Lucilene Tolentino
“Arabinoxylan rice bran (MGN-3/Biobran) provides protection against whole-body γ-irradiation in mice via restoration of hematopoietic tissues”.
J Radiat Res. 2013 May; 54(3): 419–429. Published online 2013 Jan 3. doi: 10.1093/jrr/rrs119 PMCID: PMC3650744 PMID: 23287771.

[2012 ] Karriem H. Ali, Angelica B. Melillo, Susanna M. Leonard, Deshratn Asthana, Judi M. Woolger, Aaron H. Wolfson, H. Reginald McDaniel, and John E. Lewis
“An open-label, randomized clinical trial to assess the immunomodulatory activity of a novel oligosaccharide compound in healthy adults”.
Functional Foods in Health and Disease 2012, 2(7):265-279 Page 265 of 279.

[2012 ] Biosci. Biotechnol. Biochem, 76 (5), 942-946, 2012,
“Suppressive Effect of Modified Arabinoxylan from Rice Bran (MGN-3) on D-Galactosamine-Induced IL-18 Expression and Hepatitis in Rats”.
Surina Zheng, Hiroo Sanada, Hirofumi Dohi, Shizuka Hirai, and Yukari Egashira. Laboratory of Food and Nutrition, Chiba 271-8510, Japan. Graduate school of Advance Integration Science, Chiba Univercity, 1-33 Yayoi, Inage, Chiba 263-8522, Japan

[2011 ] M. GHONEUM and S. AGRAWAL, Department of Otolaryngologt, Charles Dra, University of Medicine and Science, Los Angeles, CA,’ University of California at lrvine, Division of Basic and Clinical Immunology, Irvine, CA, USA
“Activation of Human Monocyte Derived Dendritic Cells in Vitro by the Biological Response Modifier Arabinoxylan Rice Bran (MGN-3 / Biobran)“.
Int. Journal of Immunopathology & Pharmacology Vol. 24, No 4,941-948 (2011).

[2011 ] M. GHONEUM, S. GOLLAPUDI, Department of Otolaryngology, Charles Drew University of Medicine and Science, 1621E. 120th Street, Los Angeles, CA 90059 USA, University of California at Irvine, Division of Basic and Clinical Immunology, Irvine, CA 92697.
“Synergistic apoptotic effect of Arabinoxylan rice bran (MGN-3/Biobran) and Curcumin (Turmeric) on human multiple myeloma cell line U266 in vitro”.
Neoplasma 58, 2, 2011, doi:10.4149/neo_2011_02_118

[2010] Mai Hong Bang, Tran Van Riep, Nguyen Tien Thinh, Le Huu Song, Trinh Tuan Dung, Le Van TRruong, Le Van Don, Thai Doan Ky, Deyu Pan, Magda Shaheen & Mamdooh Ghoneum
“Arabinoxylan Rice Bran (MGN-3) Enhances the Effects of Interventional Therapies for the Treatment of Hepatocellular Carcinoma: A Three-year Randomized Clinical Trial”
Anticancer Research December 2010, 30 (12) 5145-5151;

[2009 ] D. CHOLUJOVA, J. JAKUBIKOVA, J. SEDLAK, Laboratory of Tumor Immunology, Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Slovak Republic.
“BioBran-augmented maturation of human monocyte-derived dendritic cells”,
Neoplasma 56, 2, 2009

[2009] Scott Giese, George Richard Sabell & Mary Coussons-Read
“Impact of Ingestion of Rice Bran and Shitake Mushroom Extract on Lymphocyte Function and Cytokine Production in Healthy Rats”
Journal Of Dietary Supplements ISSN: 1939-0211: https://www.tandfonline.com/loi/ijds20

[2008 ] Gollapudi S, Ghoneum M. University of California at Irvine, Division of Basic and Clinical Immunology, Irvine, CA 92697, USA.
“MGN-3/Biobran, modified arabinoxylan from rice bran, sensitizes human breast cancer cells to chemotherapeutic agent, daunorubicin”.
Cancer Detection & Prevention, 2008; 32(1): 1-6. Epub 2008 Apr 11.

[2008 ] Nariman K. Badr El-Din, Noaman E. and Ghoneum M,
”In Vivo Tumor Inhibitory Effects of Nutritional Rice Bran Supplement MGN-3Biobran on Ehrlich Carcinoma-Bearing Mice”
Nutrition & Cancer, 60(2), 235-244, 2008.

[2008 ] Ghoneum M, Matsuura M. and Gollapudi S,
”Modified Arabinoxylan rice bran (MGN-3BioBran enhances intercellular killing of microbes by human phagocytic cells in vitro”
International Journal of Immunopathology & Pharmacology, Vol.21, No.1, pp.87-95 2008

[2008 ] Badr El-Din NK, Noaman E, Ghoneum M. Department of Zoology, Faculty of Science, University of Mansoura, Mansoura, Egypt.
“In vivo tumor inhibitory effects of nutritional rice bran supplement MGN-3/Biobran on Ehrlich carcinoma-bearing mice”.
Nutr Cancer. 2008;60(2):235-44.

[2006 ] Markus, A. Miller, M. Smith, I. Orengo –
“Metastatic Hemangiopericytoma of the Skin Treated with Wide Local Excision and MGN-3“
(Dermatologic Surgery -32-145-147; 2006)

[2005 ] Ghoneum M, Gollapudi S. 2005.
‘’Synergetic Role of Arabinoxylan Rice Bran (MGN-3/Biobran) in S. Cerevisiae-induced Apoptosis of Monolayer Breast Cancer MCF-7 Cells’’.
(Anticancer Res.;25: 4187-4196).

[2005 ] Ghoneum M, Gollapudi S.
“Modified arabinoxylan rice bran (MGN-3/Biobran) enhances yeast-induced apoptosis in human breast cancer cells in vitro“.
(Anticancer Res. 2005 Mar-Apr;25(2A):859-70).

[2004 ] Yasushi Okamura –
“The Clinical Significance of BioBran in the Immunotherapy of Cancer“
(Clinical Pharmacology and Therapy Vol. 14/3) [2004]

[2004 ] Hiroshi Tsunekawa –
“Effects of Long-term Administration of Immunomodulatory Food on Cancer Patients Conventional Treatments“
(Clinical Pharmacology and Therapy Vol. 14/3) [2004]

[2004 ] Takahara, K. Sano –
“The Life Prolongation and QOL Improvement Effect of Rice Bran Arabinoxylan Derivative (MGN-3, BioBran) for Progressive Cancer“
(Clinical Pharmacology and Therapy Vol. 14/3) [2004]

[2004 ] Kazutoshi Kaketani –
“A Case Where an Immunomodulatory Food was Effective in Conservative Therapy for Progressive Terminal Pancreatic Cancer“.
(Clinical Pharmacology and Therapy Vol. 14/3)

[2004 ] Kenichi Ichihashi –
“Experience with Administration of BioBran in Patients with Chronic Rheumatism“
(Clinical Pharmacology and Therapy Vol. 14/4) [2004]

[2004 ] Maeda H, Ichihashi K, Fujii T, Omura K, Zhu X, Anazawa M, Tazawa K –
“Oral administration of hydrolyzed rice bran prevents the common cold syndrome in the elderly based on its immunomodulatory action“.
(Biofactors. 2004;21(1-4):185-7).

[2004 ] Kawai T.
“One case of a patient with Umbilical Metastasis of Recurrental Cancer“
(Sister Mary Joseph’s Nodule, SMJN) Who Has Survived for a Long Time under Immunomodulatory Supplement Therapy’’,
Clinical Pharmacology and Therapy, Vol.14, No.3, pp.281-288

[2004 ] Ghoneum, M. Matsuura –
“Augmentation of macrophage phagocytosis by modifier arabinoxylan rice bran (MGN-3/BioBran)“
(Journal: International Journal of Immunopathology and Pharmacology) [2004/5/12]

[2004 ] Ghoneum, S. Abedi –
“Enhancement of natural killer cell activity of aged mice by modified arabioxylan rice bran(MGN-3/Biobran)“
(Journal: Journal of Pharmacy and Pharmacology) [2004/5/12]

[2003 ] Maeda H,
‘’The food function of Modified Arabinoxylan from Rice Bran (MGN-3)’’
Packing of Food, Vol.33, No.1, pp.45-53

[2003 ] Ghoneum M, Gollapudi S.-
“Modified arabinoxylan rice bran (MGN-3/Biobran) sensitizes human T cell leukemia cells to death receptor (CD95)-induced apoptosis“.
(Cancer Letters. 2003 Nov 10;201(1):41-9).

[2003 ] Lane Labs –
“How to pump up your immune system”
(Journal: Alternative Medicine, Jan/Feb 2003) [2003]

[2001 ] Kubo C, et. Al. 2001.
‘’The basic study of Arabinoxylan compound (MGN-3) on the activation of vital defense’’
Clinical and Research Vol.78, No.1, pp.193-196

[2000 ] Tazawa K. et al. 2000.
“Scavening activity of MGN-3 (Arabinoxylan from Rice Bran) with Natural Killer Cell Activity on Free Radicals“
Biotherapy, Vol.14, No5, pp. 493-495.

[2000 ] Ohara I., Tabuchi R., and Onai K. 2000
“Effects of Modified Rice Bran on Serum Lipids and Test Preference in Streptozotocin-Induced Diabetic Rats“,
Nutrition Research, Vol.20, No.1, pp59-68

[2000 ] Jacoby H., Wnorowski G., Sakata K., and Maeda H. 2000
‘’The Effect of MGN-3 on Induced Toxicity in the Rat’’,
Gastroenterology, Vol. 118, No.4, 4962.

[2000 ] Zhong X Lu, Karen Z Walker, Jane G Muir, Tom Mascara and Kerin O’Dea
“Arabinoxylan fiber, a byproduct of wheat flour processing, reduces the postprandial glucose response in normoglycemic subjects“
American Journal of Clinical Nutrition, Vol. 71, No. 5, 1123-1128, May 2000

[2000 ] Ghoneum M, Jewett A.
“Production of tumor necrosis factor-alpha and interferon-gamma from human peripheral blood lymphocytes by MGN-3, a modified arabinoxylan from rice bran, and its synergy with interleukin-2 in vitro“.
Cancer Detection and Prevention 2000; 24(4):314-324

[1999 ] Ghoneum M and Brown J.
“NK Immunorestoration of Cancer Patients by MGN-3, A Modified Arabinoxylan Rice Bran“
(Study of 32 patients Followed for up to 4 years)’’, Anti-Aging Medical Therapeutics

[1999 ] Maeda H.
‘’Immunopotentiation Effects of Rice Bran Arabinoxylan’’
Food Style 21, Vol.3, No.12, pp.56-58

[1999 ] Ohara I., Onai K. and Maeda H, 1999.
‘’Modified Rice Bran MGN-3, Improves Glucose Tolerance in NIDDM Adult Rats Given Streptozotocin as Neonats’’ ,
Journal of the American College of Nutrition, Vol.18, No.5, Abstract 108,549.

[1998 ] M Ghoneum –
“Anti-HIV activity in Vitro of MGN-3, an Activated Arabinoxylan from Rice Bran“.
Biochemical & [Biophysical Research Communications 243, 25-29 (1998)].

[1998 ] Ghoneum M., Drew Univercity.
“Enhancement of human natural killer cell activity by modified Arabinoxylan from rice bran (BioBran MGN-3)“.
Int. Immunotherapy XIV (2) 89-99, 1998)

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Β. Άλλες δημοσιεύσεις σχετικές με το Biobran

Ιατρική Βιβλιοθήκη του Αμερικάνικού Εθνικού Ινστιτούτου Υγείας (NCBI)
National Library of Medicine – National Institutes of Health

Science Immunology | Research Article. 21 August 2020. Coronavirus.
“Natural killer cell immunotypes related to COVID-19 disease severity”
Maucourant et al., The karolinska COVID-19 Study Group, Sci. Immunol. 5, eabd6832 (2020).

[Cancer Sci. 2018 Mar; 109(3): 863–870. Published online 2018 Feb 2. doi: 10.1111/cas.13476 PMCID: PMC5834786 PMID: 29274107
“Tumor‐associated CD204+ M2 macro-phages are unfavorable prognostic indicators in uterine cervi-cal adenocarcinoma”
Asuka Kawachi, 1 Hiroshi Yoshida, 1 Shigehisa Kitano, 2 Yoshinori Ino, 3 , 4 Tomoyasu Kato, 5 and Nobuyoshi Hiraokacorresponding author 1 , 3 , 4] . https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834786/

Crit Rev Oncog. Author manuscript; available in PMC 2015 Jan 1.
“NK Cells and Virus-Related Cancers”
Rabinarayan Mishra, Raymond M. Welsh,* and Eva Szomolanyi-Tsuda Published in final edited form as: Crit Rev Oncog. 2014; 19(0): 107–119. PMCID: PMC4196716 NIHMSID: NIHMS590333 PMID: 24941377 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196716/

Viruses. 2013 Nov; 5(11): 2624–2642. Published online 2013 Oct 28. doi: 10.3390/v5112624 PMCID: PMC3856406 PMID: 24169630
“Role of Innate Immunity against Human Papillomavirus (HPV) Infections and Effect of Adjuvants in Promoting Specific Immune Response”
Alfredo Amador-Molina,1 José Fernando Hernández-Valencia,1 Edmundo Lamoyi,2 Adriana Contreras-Paredes,1 and Marcela Li-zano1,2,* https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856406/

[J Infect Chemother. 2012 Dec;18(6):807-15. doi: 10.1007/s10156-012-0485-5. Epub 2012 Nov 3.
“Immune responses against human papillomavirus (HPV) infection and evasion of host defense in cervical cancer.”
Sasagawa T1, Takagi H, Makinoda S.] https://www.ncbi.nlm.nih.gov/pubmed/23117294